I use two, one at home and one in the office, but they both have a mixture of personal and professional items in them. Where an item goes often depends on whether it got processed at home or in the office. If I process an item in the office that needs to be actioned at home, I either put it straight in my bag to take home, or if that isn't convenient for whatever reason, I put it in the work tickler in the tab for the day I want to take it home. I work from home on Fridays, so Thursday is my last day in the office. If something needs to be actioned on a weekend and I can't take it home immediately (maybe I'm going to the theatre and don't want to carry a backpack that day, or my bag is already too full), then it would go in the tab for Thursday. When I get it home, it goes in the home tickler for the day I'm going to need it. Similarly, if I process something at home that needs to be actioned at the office, it goes in the home tickler for the day I want to take it to work, then put it in the work tickler for the day I'm going to use it.