My system is a hybrid. I find that for meetings I prefer to take notes on paper. I also use paper when I'm brainstorming or working on a primarily creative activity. My thought processes are different with a pen in my hand, rather than a keyboard.
But I LOVE using OF to ensure I have everything captured, organized, and prioritized.
My hybrid approach requires I have a way to easily get paper notes and action items into the digital world.
For that, I use a combination of Evernote and some custom software I created.
Papers that are needed for reference are photographed and land in Evernote. Papers that contain to-do items get processed with my custom software.
It let's me take a photo of my notes and it automatically extracts the parts of the photo that contain to-do items (it looks for a special marking) and puts them into my Omnifocus inbox where I can process them within my normal workflow.
No more transcribing my handwritten to-do items!
As others have said, the key is finding the balance that works for you.