The biggest advantage Bill Gates has is that he doesn't have to spend time on anything that doesn't seem important to him. He can pay people to take his car to the garage, do his laundry, clean his house, pay his bills, do his taxes, filter his email, and all of the thousands of other things that clutter up most people's lives.
The biggest disadvantage he has is that everyone wants a piece of his time. While he can say no a lot, I'll bet he has to say yes more often than he would like. For instance, the various politicians in my state couldn't care less about my tiny little business, but every politician in Washington State (and quite a few in Washington, DC) wants Gates's support for his favorite pet project.