I use my paper planner (simple half-sized, 3-ring binder notebook) for everything: personal, related to salaried work, and related to my independent/freelance work. Items related to salaried work are written in black ink; everything else is in purple (outside of salaried work, I have no need to separate "personal" and "professional"; I believe in a more fluid way of living and besides, I am the product/business - literally - for much of what I do). I use this convention for all aspects of my system: calendar, next action lists, reference notes, etc.
At the company for which I work, we are required to keep our Outlook calendars updated, so I make sure that I note meetings and other work-related appointments there in addition to noting them on my paper calendar. I have also set up personal Outlook folders in which to process and/or archive work-related e-mail, and I keep my company contacts in Outlook. Everything else related to my job - NA lists, notes, deadlines, project ideas, project notes, meeting checklists, etc. - are incorporated into my notebook. I also have a couple of reference sheets (i.e., staff phone list) in the notebook.
I like both Outlook and Access, and have created various e-checklists, NA lists, reminder systems, customized reference list, and other fancy applications for both programs for use at work. In general, however, I set these up just for fun and to keep my tech skills sharp. The paper system is what I actually use.