Some good ideas.
For me, I have several choices when this happens.
Sometimes, I do a re-boot, and come into the office over a weekend, literally starting again. If I don't complete the re-boot, I hide the old stuff collected (in a pending email folder or a cupboard). And start to deal with it 15 minutes a day, as time allows.
Btw, I often haven't got through all the old email, and it doesnt seem to matter. If it's urgent someone shouts.
Another good way that works for me is to ask for help. Sometimes, I have had a trusted assistant and had her sit with me and help me. Recently a friend came in for a couple of hours after work to sort through piles from the cupboard. Then we went out for a meal. Some years ago, I also had a dear friend who came round and helped me for several days. She understood when it was all too much, and I took to my bed! Later, we traded assistance for each other.
One of the coaches here said you dont have to be perfect. Implementing some GTD ideas, processes, hints or tips can make a difference. Thinking about it, I think one thing that really helps me if I'm low, is when I have projects well specified. That helps me know what I'm doing and why, when life's a bit hazy and tough.
And managing self talk is sooo important to me. Eradicate the back chat if you can and encourage yrself - you rock for tackling this stuff. Recognise what you are doing.
If your home gets less than organised and restful, I highly recommend FlyLady. She also rocks! You can do anything in 15 minutes or if that's too long try 2 minutes! Buy a timer for home and the office and use it. Even 2 minutes repeated several times a day, starts to show good results.